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转化生长因子的表达与肺放射性损伤的相关性研究 被引量：1

Related Research in Transforming Growth Factor β_1 Expression with Lung Injury after Irradiation
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摘要 目的探讨TGF-β1在血清中的表达及其与正常鼠肺组织放射性损伤的关系。方法33只雄性Wistar大鼠随机分为4个组,分别给予直线加速器外照射,测定TGF-β1。结果随着照射剂量增加及时间延长,血清TGF-β1水平呈升高趋势,各剂量组不同时间TGF-β1血清水平比较,差异有显著意义。结论TGF-β1参与了放射性损伤的发生发展,并在正常肺组织放射损伤中起着非常重要的作用。 Objective To discuss the relationship between TGF-β1 expression and lung injury after irradiation. Methods Wistar adult male mice were divided four groups at random and they were radiated by line accelerator and measure the TGF-β1. Results with the addition of irradiation dose and prolong of the time, the level of the plasma TGF-β1 elevated. Plasma TGF-β1 of post radiation were higher than pre-radiation. The difference was significance. Conclusion TGF-β1 involves in the development,progress of the radiation induced lung damage. It plays an important role in the lung damage by radiation.
作者 姚鸿民
机构地区 辽宁省肿瘤医院
出处 《中国现代医生》 2008年第14期27-29,共3页 China Modern Doctor
关键词 TGF-Β1 肺放射性损伤 表达 研究 直线加速器 TGF-β1 Lung injury Expression Research Line accelerator
分类号 R818.74 [医药卫生—放射医学]
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参考文献13

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同被引文献7

  • 1Anscher MS, Kong FM, Jirtle RL, et al. The releveance of transforming growth factor betal in pulmonary injury aider radiation therapy[J].Lung Cancer, 1998, 19(2): 109-20.
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  • 3Rubea CE, Wilferta F, Danielab U, et al. Modulation of radiation- induced tumour necrosis factor α(TNF-α) expression in the lung tissue by pentoxifylline[J]. Radiother Oncol, 2002, 64(2): 177-87.
  • 4Santana A, Saxena B, Nancy A, et al. Increased expression of transforming growth factor β(β1,β2,β3) in blemyein-induced pulmonary fibrosis[J].Am J Pespir Cell Mol Biol, 1995, 13(1): 34-44.
  • 5杨明会,窦永起,林明雄,冯林春,刘毅,杨艳.不同剂量凉血活血方防治大鼠放射性肺损伤的研究[J].中国中西医结合急救杂志,2008,15(1):6-8. 被引量：6
  • 6崔晓利,刘海玲,董秀怠,殷蔚伯.转化生长因子β_1表达在小鼠放射性肺纤维化形成过程中的作用[J].中华放射肿瘤学杂志,1999,8(1):47-49. 被引量：28
  • 7曹京旭,张旭志.细胞因子与放射性肺损伤[J].国外医学（放射医学核医学分册）,2001,25(4):181-185. 被引量：41

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中国现代医生
2008年 第14期

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