40例舌癌组织VEGF表达及微血管密度观察

Observation of VEGF expression and microvessel density in 40 human tongue squamous carcinomas.

目的:探讨血管内皮生长因子(VEGF)表达及微血管密度(MVD)与舌癌组织临床病理指标的关系。方法:40例手术切除的舌癌原发病灶蜡块标本常规切片,免疫组化染色法观察各标本VEGF表达及MVD。结果:VEGF阳性表达的舌癌组织有较高的微血管密度(p<0.01);VEGF表达和MVD在淋巴结转移组间有显著性差异(p<0.01)、病理分型组间有显著性差异(p<0.05),而在原发病灶临床分级组间差异无统计学意义(p>0.05)。结论:VEGF表达和MVD与舌癌病理分型及淋巴转移关系密切,可作为预测性检测指标。

Objective： To investigate expression of vascular endothelial growth factor （VEGF） and microvessel density （MVD） in human tongue cancer tumors and the relationship of VEGF and MVD with clinicopathologic. Method： The specimens of human tongue squamous carcinoma from 40 patients were collected after operation. The expression of VEGF and MVD were observed by immunohistochemical staining, respectively.Result： Tongue cancer tumors with positive VEGF expression have higher microvessel density compared to VEGF negative tumors （P 〈 0.01）.The VEGF expression and MVD make difference in lymph node metastasis groups （P 〈 0.01） and in tumor differentiation degree groups （P 〈 0.05）.But there are no statistically significant difference of those in original tumor size groups （P 〉 0.05）.Conclusion：The expression of VEGF make a important role in angiogenesis and lymph node metastasis of human tongue squamous carcinoma.Detection ofVEGF and MVD may be useful to evaluate prognosis of human tongue squamous carcinoma.