异丙酚对大鼠肺动脉压及缺氧性肺血管收缩反应的影响

The effect of propofol on pulmonary artery pressure and hypoxic pulmonary vasoconstriction reaction in rat

目的:观察不同剂量异丙酚对肺动脉压及缺氧性肺血管收缩反应(HPV)的影响。方法:采用离体大鼠全血灌注肺模型。结果:空气+4％CO_2通气条件下肺动脉压为1.78±0.24kPa,分别给予异丙酚4mg/kg、6mg/kg、8mg/kg,MPAP分别下降至1.53±0.25kPa、1.40±0.23kPa、1.38±0.24kPa,与给药前相比MPAP明显降低,6mg/kg和8mg/kg异丙酚降压作用明显强于4mg/kg。吸入气为混合气(3％O_2+4％CO_2+93％N_2)情况下肺动脉压从1.60±0.23kPa上升至2.38±0.31kPa。分别给予异丙酚4mg/kg、6mg/kg、8mg/kg。MPAP分别降至2.01±O.35kPa、1.85±0.37kPa、1.83±O.41kPa,抑制缺氧性肺动脉升压反应分别为47％、67％、71％。且6mg/kg和8mg/kg与4mg/kg相比抑制程度有显著差异。结论:异丙酚可降低肺动脉压及抑制缺氧性肺血管收缩反应,且与剂量有关。

Objective:To investigate the effect of dosages of propofol on pulmonary artery pressure (PAP) and hypoxic pulmonary vasoconstriction(HPV) reaction. Method:Isolated rat lungs were perfused with whole blood at the rate of flow 10ml/min and ventilated with air+4％CO_2(n=5) or 3％ O_2+4％CO_2+93％ N_2(mixed gas, n=11).PAP was measured continuously during the whole procedure. Result:PAP decreased significantly in air+4％ CO_2 ventilation following administralion of propofol 4 mg/kg,6 mg/kg and 8 mg/kg respectively.The varied degrees at 6 mg/kg and 8mg/kg were even more marked than that at 4mg/kg. When mixed gas was ventilated into lung, PAP increased from 1.60+0.23kPa to 2.384±0.31kPa to produce HPV,PAP decreased abruptly in HPV rats when administered 4mg/kg, 6mg/kg and 8mmg/kg propofol respectively and HPV reaction was inhibited by 47％, 867％and 71％ respectively,the inhibition extent was more at 6mg/kg or 8mg/kg than that at 4mg/kg. Conclusion:Propofol can decrease PAP and inhibite HPV in dose-dependent way.