纳洛酮治疗急性一氧化碳中毒

Naloxone in treating acute carbon monoxide poisoning

目的：探索纳洛酮对急性一氧化碳中毒的疗效。方法：治疗组２１例（男性１６例，女性５例；年龄３９±ｓ１９ａ）除常规治疗外，加用纳洛酮１．２～１．６ｍｇ溶于５％葡萄糖２０ｍＬ中静脉推注，ｑｈ，直至病人清醒；对照组２０例（男性１５例，女性５例，年龄４１±２０ａ）用纠正缺氧、预防脑水肿、保持呼吸道通畅等常规治疗。结果：治疗组与对照组平均促醒时间对中度中毒分别为１．２±０．４ｈ和２．６±０．６ｈ（Ｐ＜０．０１），重度中毒分别为８．７±１．２ｈ和１３±４ｈ（Ｐ＜０．０５）。结论：纳洛酮在急性一氧化碳中毒的治疗上有效。

AIM: To explore the effect of naloxone in treating carbon monoxide (CO) poisoning. METHODS: Twenty-one patients with CO poisoning (M 16, F 5, age 39±s 19 a) were treated with naloxone 1.2-1.6 mg in 5% glucose 20 mL, iv, qh, until the patients woke up besides conventional therapy; another 20 patients belong to control group (M 15, F 5, age 41±20 a) treated with preventing cerebral edema, remaining respiratory tract unobstruct, correcting the state of oxygen lacking etc. conventional therapy. RESULTS: The awaken times of middle and severe poisoning were 1.2±0.4 h, 2.6±0.6 h and 8.7±1.2 h, 13±4 h respectively (P<0.01 or 0.05). CONCLUSION: Naloxone is an effective drug in the treatment of CO poisoning.