雷帕霉素对实验性自身溶血性贫血小鼠抗自身红细胞抗体产生的抑制作用

Inhibitory Effect of Rapamycin on the Production of Anti-Erythro- cyte Autoantibodies in a Model of Experimental Mouse Hemolytic Anemia

作者介绍了一种自身免疫病的实验模型,并研究了抗真菌抗生素雷帕霉素（rapamycin;RPM）对实验性自身溶血性贫血小鼠产生抗自身红细胞抗体的预防和治疗作用、结果表明,口服2.5～10mg/kg的RPM可有效预防小鼠实验性抗自身红细胞抗体滴度的升高,并维持在1:32左右,且停药后不存在反跳现象。同时RPM也能在一定程度上抑制抗大鼠红细胞抗体的产生。此外RPM还表现了很好的治疗作用,它能使已升高的抗自身红细胞抗体滴度显著降低。与环孢菌素相比.雷帕霉素具有更强的抑制抗自身红细胞抗体产生的作用。

A model of experimental mouse hemolytic anemia was introduced in this paper, and the preventive and therapeutic effects of rapamycin (RPM) on the production of anti-erythrocyte au-toantibodies and anti-rat erythrocyte antibodies were investigated with this model. The results indicated that RPM strongly prevented the production of anti-erythrocyte autoantibodies at a dose range of 2. 5-10mg/(kg . d) (p. o. )for two weeks from day-1. It kept the autoantibodies at a lower level of 1 : 32 without rebounding. RPM also showed a moderately inhibitory effect on the production of anti-rat erythrocyte antibodies. In addition, RPM showed significantly therapeutic effect to reduce the produced anti-erythrocyte autoantibodies to a lower level by oral administration of 5mg/ (kg d) from day 14 to 28 and day 21 to 35. This therapeutic effect is much better than that of cy-closporine showing in our previousely paper[2].