摘要
青蒿琥酯能松弛豚鼠气管平滑肌，并能非竞争性拮抗乙酰胆碱、组织胺的缩气管作用。β肾上腺素受体阻断剂噻吗洛尔不能阻断青蒿琥酯的松驰气管作用；青蒿琥酯对豚鼠气管组织腺苷酸环化酶活性呈药物浓度依赖性明显的激活作用。在一定剂量范围内，药物浓度与酶的激活作用呈明显的线性关系。
Artesunate was capable to relax tracheal smooth muscle, and able to antagonize non competitively the effects of spasmogens like Acetylcholine and Histamine on trachea from guinea pig. Timolol, a nonselective blocker of the beta adrenalinergic receptor, was not able to inhibit the relaxant action of Artesunate. Artesunate had an action to activate significantly the adenylate cyclase of tracheal tissue from guinea pig in a concentration dependent manner. The concentration of Artesunate and this activated action present significant linear relationship in the given concentration ranges. These results indicated that the relaxant effects of Artesunate on tracheal smooth muscle were related to its action on the activation of adenylate cyclase.
出处
《中山医科大学学报》
CSCD
1997年第4期264-267,共4页
Academic Journal of Sun Yat-sen University of Medical Sciences
关键词
青蒿素
气管平滑肌
青蒿琥酯
artemisinin/analogs & derivatwes
artemisinin/pharmacology
succinates/pharmacology
trachea/drug effects
adenyl cyclase/drug effects
