传入信息在十二指肠内高渗盐溶液抑制胃内蛋白胨引起胃酸和血流增加效应中的作用

Role of Afferent Messages in the Inhibitiory Effects of the Duodenal Infusion of hyperosmotic Solution on the Intragastric Peptone Causing the Increase of GAO and GMBF

采用氢气清除法测定胃粘膜血流量（ｇａｓｔｒｉｃｍｕｃｏｓａｌｂｌｏｏｄｆｌｏｗ，ＧＭＢＦ），用利多卡因消除十二指肠粘膜传入信息，观察传入信息在十二指肠灌注高渗溶液抑制蛋白胨引起胃酸分泌和胃粘膜血流量增加效应中的作用。结果发现：（１）胃内灌注６％蛋白胨引起胃酸分泌和ＧＭＢＦ显著增加；（２）十二指肠灌注高渗盐溶液使胃内蛋白胨刺激胃酸分泌和ＧＭＢＦ增加的作用减弱；（３）用利多卡因消除传入信息后，十二指肠灌注高渗盐溶液对胃内蛋白胨引起的胃酸分泌和ＧＭＢＦ具有抑制作用。提示十二指肠传入信息参与了高渗盐溶液对胃内蛋白胨引起胃酸分泌和ＧＭＢＦ增加的抑制效应。

By the use of hydrogen gas clearance technique, we investigated the role of duodenal afferent messages in the inhibitory effects induced by duodenal infusion of hyperosmotic solution on gastric acid output(GAO) and GMBF response to intragastric peptone perfusion. The results were as follows: (1)intragastric peptone perfusion promoted GAO and increased GMBF significantly; (2) duodenal infusion of hyperosmotic solution might significantly inhibit the GAO and GMBF response to intragastric peptone perfusion; (3) the effects of duodenal infusion of hyperosmotic solution on GAO and GMBF response to intragastric peptone perfusion were inhibited by duodenal infusion of lidocaine. The results showed that duodenal afferent messages were involved in the inhibitory effects of GAO and GMBF response to intragastric peptone during duodenal infusion of hyperosmotic solution.