N-(5-芳基-1,3,4-二唑-2-基)-N'-4-硝基苯氧乙酰基硫脲的合成及生物活性

Synthesis and Biological Activities of N-(5-Aryl-1,3,4-thiadiazol-2-yl) -N'-4-nitrobenzoxyacetylthioureas

为了寻找更好的生物活性化合物,从4-硝基苯氧乙酸出发合成酰基异硫氰酸酯,然后与2-氨基-5-芳基-1,3,4-二唑反应合成了10个新的酰基硫脲类化合物;其结构经红外光谱、核磁共振氢谱、质谱和元素分析确认。同时对6种病原菌进行了生物活性测试,结果表明:在50mg/L质量浓度下,大部分化合物对黄瓜灰霉病菌和小麦赤霉病菌抑制效果较好,抑制率达50%以上,且优于对照商品醚菌酯;特别是Ⅱh、Ⅱi化合物对黄瓜灰霉病菌抑制率达85%。

In order to search compounds of better fungicidal activity, ten new N-（5-aryl-1,3,4-thiadiazol-2-yl）-N＇-4- nitrobenzoxyacetylthioureas were synthesized from the start material of 4-nitrobenzoxyacetic acid.Their structures had been confirmed by IR, MS, ^1H NMR and Elemental Analysis. The results of biological test showed that some of these compounds had good fungicidal activity. The inhibition rate of most compounds to Botrytis cinerea Pers and Gibberella zeae coud reach 50% at the concentration of 50 mg/L. The inhibition rate of two compounds to Botrytis cinereapers were 85%.