西酞普兰与阿米替林对老年抑郁症患者生活质量影响的对比研究

Comparative study on effect of citalopram and amitriptyline on quality of life in senile depression patients

目的比较西酞普兰与阿米替林对老年抑郁症患者生活质量的影响。方法将86例老年抑郁症住院患者随机分为两组,分别给予西酞普兰和阿米替林治疗8周,并采用生活质量综合评定问卷(GQOLI-74)、汉密顿抑郁量表(HAMD)和副反应量表(TESS)于治疗前和治疗8周末对生活质量、疗效及安全性进行评定。结果西酞普兰与阿米替林对老年抑郁症的疗效相似(P>0.05),但前者不良反应少(P<0.01),对于患者生活质量的改善显著优于后者(P<0.01)。结论与阿米替林相比,西酞普兰能更好地改善老年抑郁症患者的生活质量。

Objective To compare the efficacy of citalopram and amitriptyline on the quality of life in senile depression patients. Methods Eighty six inpatients with senile depression were assigned randomly to citalopram group or amitriptyline group for 8 weeks. The quality of life,efficacy and side effect were assessed with Generic Quality of Life Inventory-74 （GQOLI-74）, Hamilton Depression Rating Scale（HAMD）and Treatment Emergent Symptom Scale（TESS） before and 8 weeks after the treatment respec- tively. Results The efficacy of citalopram was similar to that of amitriptyline（P〉0.05） ,but citalopram had fewer side effects（P〈0.01）. Citalopramt s healthy dimensionalities of body, mental and social function were superior to that of amitriptyline （P〈 0.01 ）. Conclusion Compared with amitriptyline,citalopram can improve the quality of life in senile depression patients.