盐酸戊乙奎醚用于儿童支气管镜检查术前的研究

A Clinical Study on Penehyclidine Hydrochloride as Premedication of General Anesthesia

目的评价盐酸戊乙奎醚作为儿童支气管镜检查术前用药的有效性与安全性。方法本研究采用随机双盲平行对照观察。98例患儿随机分为3组,术前分别肌注阿托品、盐酸戊乙奎醚和注射用水,测定注射后15min、30min唾液分泌量。用视觉模拟评分(VAS)方法测定口干程度,记录不良反应。结果给药30min后,阿托品组、盐酸戊乙奎醚组、注射用水组唾液分泌量分别较给药前变化(-16.88±17.72)、(-19.22±18.78)、(-2.66±16.69)mg。给药30min后,阿托品、盐酸戊乙奎醚和注射用水组HR分别较给药前变化(82.1±19.64)、(-5.72±9.89)和(-0.75±7.01)次/min。观察期间无严重不良反应。结论盐酸戊乙奎醚作为儿童支气管镜术前用药,可明显减少唾液分泌,无HR增快,无明显不良反应。

Objective To evaluate the effectiveness and safety of penehyclidine hydrocliloride as a preoperative treatment for children bronchoscopy, Methods This study used randomized, double-blind and parallel-controlled observation.98 cases were randomly divided into three groups, respectively intramuscular injection of atropine, penehyclidine hydrochloride and water. The salivary secretion was determined after injection 15 min and 30 min, The content of drymouth was measured with VAS method and adverse reactions were recorded. Results After 30 min, salivary secretion changes were （ - 16.88 ±17,72）, （ - 19.22 ± 18, 78） （ -2.66± 16.69） mg in atropine group,penehyclidine hydrochloride group and water group respectively, The HR changes were （82.1 ±19.64）, （ - 5.72 ± 9.89） and （ - 0.75 ± 7.01） per min in astropine group, penehyclidine hydrochloride group and water group respectively after 30 min administration, Conclusion Penehyclidine hydrochloride is safe and effective as children bronchoscopy preoperative medication.