脑转移出现的时机对非小细胞肺癌预后的影响

Effect of Brain Metastasis Appearing Time on Survival of Patients with Non Small Cell Lung Cancer

目的:了解非小细胞肺癌脑转移出现的时机对生存期的影响。方法:选择1999/2006年在我院死亡的非小细胞肺癌病例238例,男159例,女79例。腺癌162例,鳞癌76例。结果:非小细胞肺癌患者初诊时出现脑转移对生存有显著影响,中位生存(12±1)个月,P=0.000 4,在患病期间出现脑与非脑转移对生存期影响差异无显著性,首发转移时有无脑转移都对生存期影响差异无显著性。结论:非小细胞肺癌初次诊断时出现脑转移对预后有显著影响。

Objective：To discuss the effect of brain metastasis appearing time on non small cell lung cancer patient survival. Methods ：Two hundred thirty eight patients with non small cell lung cancer were chosen from 1999 to 2006 ,and they were dead in our hospital. Male patients were 159 cases, female 79 cases, adenocarcinoma 162 cases, squamous cancer 76 cases. Results：The brain metastasis at initial diagnosis was significant for prognosis, the median survival was 12＋1 m when brain metastasis appeared at initial diagnosis （P= 0.000 4）,there was no significant difference between brain metastasis and non-brain metastasis during whole life or when first metastasis appearing. Conclusion： The brain metastasis at initial diagnosis is a prognosis factor for non small cell lung cancer.