N-(4-乙酰氨基)苯基-3-羟基-2-萘甲酰胺的合成研究

Study on the Synthesis of N-(4-Acetylamino)phenyl-3-hydroxy-2-naphthalenecarboxamide

以２，３－酸和对氨基乙酰苯胺为原料合成Ｎ－（４－乙酰氨基）苯基－３－羟基－２－萘甲酰胺，研究了二种合成方法对产品纯度的影响，实验证明了钠盐法优于酸式法，产品含量＞９８％，反应收率８１８％。

N-(4-Acetylamino)phenyl-3-hydroxy-2-naphthalenecarboxamide was prepared by N-acylation of 4-aminoacetanilide with 2-hydroxy-3-naphthoic acid or its sodium salt.The reaction conditions were studied.The yield and purity of two methods were 80.8% and 95% (acid method),81.8% and >98% (sodium salt method).