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柚皮甙、橙皮甙和儿茶素硫酸酯的合成及其HPLC-MS的鉴定

Synthesis and HPLC-MS identification of naringin,hesperidin and catechin sulfate
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摘要 目的合成柚皮甙、橙皮甙、儿茶素硫酸酯。方法柚皮甙、橙皮甙、儿茶素在冰浴中与浓硫酸反应2 h,用6N NaOH终止反应。衍生物用高效液相色谱(HPLC)-大气压化学电离(APCI)-质谱(MS)联用鉴定。结果和结论有柚皮甙、橙皮甙和儿茶素硫酸酯的生成。 Objective To synthesize and identify the naringin, hesperidin and catechin sulfate. Methods Naringin, hesperidin and catechin were esterified with concentrated sulfuric acid for 2 hours in ice bath, and then terminated by 6N NaOH. Derivatives were identified by HPLC-APCI-MS. Results and Conclusion Naringin, hesperidin and catechin sulfate were produced.
作者 刘文 段宁 李慧 张莹 邓亦峰 梁念慈
机构地区 广东医学院生物化学与分子生物学研究所 广东医学院第一临床学院 广东医学院天然药物研究与开发重点实验室
出处 《广东医学院学报》 2008年第2期120-121,134,共3页 Journal of Guangdong Medical College
基金 广东省重点学科基金资助(No:9306)
关键词 柚皮甙 橙皮甙 儿茶素 高效液相色谱-质谱联用 naringin hesperidin catechin HPLC-MS
分类号 R977.29 [医药卫生—药品]
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参考文献7

  • 1杨宏亮,田珩,李沛波,王永刚,苏薇薇.柚皮苷及柚皮素的生物活性研究[J].中药材,2007,30(6):752-754. 被引量：76
  • 2Tsui V W, Wong R W, Rabie A B. The inhibitory effects of naringin on the growth of periodontal pathogens in vitro[J]. Phytother Res, 2007,22(3) :401-406.
  • 3Benkovic V, Orsolic N, Knezevic A H, et al. Evaluation of the radioprotective effects of propolis and flavonoids in gammairradiated mice: the alkaline comet astray study [J]. Biol Pharm Bull,2008,31(1): 167-172.
  • 4徐春,徐萌萌,王建芳,张韬,钱磊,任浙丹,孙启玲.橙皮素的药效研究及应用[J].天然产物分离,2006,4(6):1-3. 被引量：10
  • 5Choi I Y, Kim S J, Jeong H J, et al. Hesperidin inhibits expression of hypoxia[ J ]. Cell Biochem, 2007,305 ( 1/2 ) : 153- 161.
  • 6刘超,陈若芸.儿茶素及其类似物的化学和生物活性研究进展[J].中国中药杂志,2004,29(10):1017-1021. 被引量：52
  • 7Bettuzzi S, Rizzi F, Belloni L. Clinical relevance of the inhibitory effect of green tea catechins (GtCs) on prostate cancer progression in combination with molecular profiling of catechin-resistant tumors: an integrated view[J]. Pol J Vet Sci, 2007,10(1) :57-60.

二级参考文献58

  • 1Korver O, Wilkins C K. Circular dichroism spectra of flavanols. Tetrahedron, 1971,27:5459.
  • 2Bilia A R, Morelli I, Hamburger M, et al. Flavans and a-type proanthocyanidins from Prunus prostrata. Phytochemistry, 1996,43 (4): 887.
  • 3Nonaka G, Kawahara O, Nishioka I. Tannins and related compounds. XV. A new class of dimeric flavan-3-ol gallates, theasinensins A and B, and proanthocyanidin gallates from green tea leaf. Chem Pharm Bull, 1983,31 (11): 3906.
  • 4Coxon D T, Holmes A, Ollis W D, et al. Flavanol digallates in green tea leaf. Tetrahedron, 1972,28:2819.
  • 5Young E, Brandt E V, Young D A, et al. Oligomeric (2R,3S)-3,3′,4′,7,8-pentahydroxyflavans: atropisomerism and conformation of biphenyl and m-terphenyl analogues from Prosopis glandulosa (‘Mesquite'). J Chem Soc Perkin Trans I, 1986:1737.
  • 6Malan E, Roux D G. Flavonoids and tannins of Acacia species. Phytochemistry, 1975,14:1835.
  • 7Steynberg P J, Steynberg J P, Ferreira D, et al. Structure and synthesis of the first profisetinidins with epifisetinidol constituent units. J Chem Soc Perkin Trans I, 1997:1943.
  • 8Chung M I, Lai M H, Yen M H, et al. Phenolics from Hypericum geminifloum. Phytochemistry, 1997,44 (5): 943.
  • 9Samaraweera U, Sotheeswaran S, Uvais M, et al. 3,5,7,3′,5′-Pentahydroxyflavan and 3α-methoxyfriedelan from Humboldtia laurifolia. Phytochemistry, 1983,22 (2): 565.
  • 10Takani M, Nakano M, Takahashi K. Studies on constituents of medicinal plants. XIX. Constituents of Schizandra nigra Max. Chem Pharm Bull, 1977,25 (12): 3388.

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广东医学院学报
2008年 第2期

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