2型糖尿病患者尿微量蛋白测定的临床价值分析

Clinical Significance of Urinary Micro-Protein in Type 2 Diabetic Patients

目的探讨2型糖尿病患者3种尿微量蛋白水平及与早期肾脏损害的关系。方法采用放免法测定20例正常人及48例2型糖尿病患者尿α1-微球蛋白、β2-微球蛋白及白蛋白水平。结果2型糖尿病组尿α1-微球蛋白、β2-微球蛋白及尿微量白蛋白水平均明显高于对照组,差异有统计学意义(P<0.01)。结论尿α1-微球蛋白、β2-微球蛋白及白蛋白水平测定对2型糖尿病早期肾损害的诊断有一定价值。

Objective To study the relationship between the three kinds of urinary protein and early kidney damage in patients with type 2 diabetes. Methods Radioimmuno-assay was applied to detect the levels of urine α1-microglobulin（α1 -MG） ,β2-microglobulin（β2-MG） ,and albumin（Alb） in 48 patients with type 2 Diabetes and 20 heahhy persons, Results The level of urine α1-MG, β2-MG and Alb in type 2 Diahetic patients were higher than that of control group（ P 〈 0.01 ）. Conclusions The determination of urine α1-MG, β2-MG,and Alb may be useful to the diagnosis of type 2 Diabetic Nephropathy.