动物热激转录因子的进化类型及其功能研究进展

The Evolution Types and Function of Animal Heat Shock Transcription Factors

生物体暴露在高温和其它一些化学或者生理胁迫的环境中能诱导机体产生热激蛋白。真核生物中热激蛋白基因的表达受热激转录因子的调节。正常生长条件下,热激转录因子呈无活性的单体状态,当生物体处在热激等胁迫环境中时,热激转录因子会立即转换成有活性的三聚体并进入细胞核中与热激蛋白基因的热激元件结合,从而激活热蛋白激基因的转录。综述了近年来4种热激转录因子在生物体热应激反应中的作用,重点讨论了热激转录因子家族成员功能上的新发现。

Organisms respond to elevated temperatures and to chemical and physiological stresses by increasing the synthesis of heat shock proteins （HSPs）. The expression of heat shock protein genes in eukaryotes is regulated by heat shock transcription factor （HSF）. HSF exists in a relatively inactive state in unstressed cells,and is activated upon heat shock,then trimerization,which have higher affinity binding to the HSE in the up-stream of hsp gene and transcriptional activity. The role of Four HSFs in the heat shock response are described in this review,with the emphasis on novel discoverises on the differential functions of the HSF family members.