奥曲肽选择性动脉介入治疗重症急性胰腺炎临床观察

Octreotide in selective artery interventional therapy for severe acute pancreatitis

目的：观察奥曲肽选择性动脉介入治疗重症急性胰腺炎（SAP）的疗效。方法：将63例SAP患者分为对照组和治疗组,对照组36例采用常规治疗,治疗组27例除常规治疗外,采用数字减影血管造影（DSA）,根据CT检查所示胰腺病变部位将导管插入胰腺供血动脉,每6 h经导管注入奥曲肽0.1 mg,疗程3-7天。比较两组疗效。结果：治疗组血液淀粉酶较对照组下降迅速,胃肠减压量治疗组与对照组差异有统计学意义（P〈0.01）,临床治愈时间治疗组比对照组明显缩短（P〈0.01）,并发症发生率、中转手术率和病死率,治疗组分别为14.81%、3.70%和0.00%,对照组分别为44.44%、22.22%和16.67%。结论：奥曲肽介入治疗SAP疗效显著,且优于常规治疗。

Objective： To observe the effect of selective artery interventional therapy with octreotide on severe acute pancreatitis （SAP）. Methods：Sixty-three SAP patients were divided into control group （36 cases ） and treatment group （27 cases ）. The control group received only the routine therapy,while the the treatment group received interventional therapy in addition to the routine therapy. A catheter was placed to the pancreas feeding artery according to CT check and digital subtraction angiography（DSA） device, and oetreotide 0.1 mg was supplied every 6 h for 3 to 7 days. The curative effects of the two groups were compared. Results ： The blood amylase reduced more quickly in the treatment group than in control group. The gastrointestinal decompression was significantly different between the two groups （P 〈 0.01 ） and the treatment time was shortened obviously in the treatment group （P 〈 0.01 ）. The complication incidence rate,change surgery rate and fatality rate were 14.81% ,3.70% and 0.00% ,in the treatment group, and 44.44% ,22.22% and 16.67 % in the control group,respectively. Conclusions ：The curative effect of interventional therapy using octreotide is much better than the routine therapy for SAP.