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CYP2J2的生理功能及其在心血管疾病中的作用 被引量：1

Physiological Functions of CYP2J2 and its Influence on Cardiovascular Diseases
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摘要 CYP2J2是一种广泛存在于人体心血管系统、肾脏及肝脏的P450酶。在人体不仅参与外源性物质的代谢,同时还参与花生四烯酸的代谢。由于其分布与功能的特点,在人体心血管系统具有重要调控作用。现就CYP2J2的基因及相应突变,分布以及其生理功能进行简单综述。 As one of Human cytochromes P450,CYP2J2 is abundant in cardiovascular tissue and active in the metabolism of a variety of xenobiotics and arachidonic acid that make it to be one of the most important factor in cardiovascular system.This minireview will provide a general overview of CYP2J2 gene and its polymorphisms,distribution and physiological functions.
作者 李钟玉 周宏灏
机构地区 中南大学临床药理研究所
出处 《医学综述》 2008年第11期1619-1622,共4页 Medical Recapitulate
关键词 CYP2J2 环氧-二十碳三烯酸 基因多态性 心血管疾病 CYP2J2 Expoxyeicosatrienoic acid Gene polymorphism Cardiovascular diseases
分类号 R329 [医药卫生—人体解剖和组织胚胎学] R394 [医药卫生—医学遗传学]
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参考文献27

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同被引文献21

  • 1Seliskar M,Rozman D. Mammalian cytochromes P450 improtance of tissue specificity[J].Biochim Biopys Acta,2007,(03):458-66.
  • 2Paine MF,Hart HL,Ludington SS. The human intestinal cytochrome P450 "pie"[J].Drug Metabolism and Disposition,2006,(05):880-6.
  • 3Alexandrov K,Rojas M,Rolando C. DNA damage by benzo(a)pyrene in human cells is increased by cigarette smoke and decreased by a filter containing rosemary extract,which lowers free radicals[J].Cancer Research,2006,(24):11938-45.
  • 4Wang TL,Li HL,Tiong WY. Genetic contribute to patients pecific warfarin dose for Han Chinese[J].Clinica Chimica Acta,2008,(1/2):76-9.
  • 5Simon C,Stieger B,Kullak-Ublick GA. Intestinal expression of cytochrome P450 enzymes and ABC transporters and carbamazepine and phenytoin disposition[J].Acta Neurologica Scandinavica,2007,(04):232-42.
  • 6Hayashi M,Matsumoto N,Takenoshita-Nakaya S. Individual metabolic capacity evaluation of cytochrome P450 2C19 by protein and activity in the small intestinal mucosa of Japanese pancreatoduodenectomy patients[J].Biological and Pharmaceutical Bulletin,2011,(01):71-6.
  • 7Hosohata K,Masuda S,Katsura T. Impact of intestinal CYP2C19 genotypes on the interaction between tacrolimus and omeprazole,but not lansoprazole,in adult living-donor liver transplant patients[J].Drug Metabolism and Disposition,2009,(04):821-6.
  • 8Leon DJ,Susce MT,Murray-Carmichael E. The Amp liChip CYP450 genotyping test:integrating a new clinical tool[J].MOLECULAR DIAGNOSIS & THERAPY,2006,(03):135-51.
  • 9Slanar O,Nobilis M,Kvetina J. CYP2D6 polymorphism,tramadol pharmacokinetics and papillary response[J].European Journal of Clinical Pharmacology,2006,(01):75-6.
  • 10Pedersen RS,Damkier P,Brosen K. Enantioselective pharmacokinetics of tramadol in CYP2D6 extensive and poor metabolizers[J].European Journal of Clinical Pharmacology,2006,(07):513-21.

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医学综述
2008年 第11期

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