慢性阻塞性肺疾病与白细胞介素9和干扰素γ的关系

Relationship of Chronic Obstructive Pulmonary Disease with Interleukin 9 and Interferon gamma

慢性阻塞性肺疾病(COPD)是气道的多因子疾病,COPD的慢性气道炎症是由非常复杂的相互作用的细胞因子构成的网络调控的。白细胞介素9(IL-9)mRNA的表达可能刺激气道黏液产生过多,气道平滑肌增生、重塑,从而导致气流阻塞、气道高反应性。干扰素γ(IFN-γ)作为Th1细胞因子,可通过刺激巨噬细胞、激活中性粒细胞等,使蛋白酶-抗蛋白酶系统失衡而在COPD气道炎症中起作用。IFN-γ与IL-9相互调节,在COPD发病机制中起作用。

Chronic obstructive pulmonary disease（COPD）is a multifactorial disease of the airways,Chronic airway inflammation in COPD is regulated by a highly complex network of mutually interacting cytokines.The expression of interleukin-9（IL-9）may be directly involved in mucus hypersecretion,airway smooth-muscle hyperplasia,and remodeling,which then result in airway obstruction and airway hyperresponsiveness.interferon-γ（IFN-γ）as a Th1 cytokines,induces activation of alveolar macrophages and neutrophil,and then result in unbalance between protease and antiprotease,which play an important role in the airway inflammation of COPD.The interaction between.IL9 and IFNγ plays an important role in the pathogenesis of COPD.