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CD_4^+CD_(25)^+调节性T细胞在移植物抗宿主病中作用的研究 被引量：3

Effect of CD_4^+CD_(25)^+ Regulatory T Cells in the Graft-Versus-Host Disease
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摘要 目前异基因造血干细胞移植已广泛应用于血液系统恶性肿瘤的治疗,但其产生的移植物抗宿主病(GVHD)是影响其治疗效果的最严重的并发症之一。近来有研究表明,CD4+CD2+5调节性T细胞具有预防和治疗GVHD的作用。现就CD4+CD2+5调节性T细胞的特性以及在GVHD中的作用简要综述。 Allogeneic hemotopoietic stem cell transplantation（allo-HSCT）has been widely applied in the treatment for hematological malignancies at present.while,the graft versus host disease（GVHD）is one of the most severe complications of allo-HSCT,which can affect its therapeutic effect on hematologic disease.Recently,some studies indicated that CD4^ ＋CD25 ^＋ regulatory T cells can effectively prevent and cure GVHD.This article reviews the characteristics of CD4 ^＋CD25^ ＋ regulatory T cells and its effect on GVHD.
作者 邵亮 刘昆 张铀 杨红
机构地区 昆明医学院第二附属医院血液科
出处 《医学综述》 2008年第11期1633-1635,共3页 Medical Recapitulate
关键词 血液 肿瘤 CD4^+CD25^+调节性T细胞 移植物抗宿主病 异基因造血干细胞移植 Blood Tumor CD4^ ＋CD25 ^＋ regulatory T cells Graft-versus-host disease Allogeneic hematopoietic stem cell transplantation
分类号 R73-35 [医药卫生—肿瘤]
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参考文献21

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  • 2吴德沛,李彩霞.调节性T细胞与移植物抗宿主病相关性的研究进展[J].临床内科杂志,2006,23(9):584-587. 被引量：1
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二级参考文献56

  • 1Sakaguchi S. Regulatory T cells: key controllers of immunologic self-tolerance[J]. Cell, 2000, 101(5): 455-458.
  • 2Shevach EM. CD4^+CD25^+ suppressor T cells: more questions than answers[J]. Nature Rev Immunol, 2002, 2(6): 389-400.
  • 3Anderson MS, Venanzi ES, Klein L, et al. Projection of an immunological self shadow within the thymus by the aire protein[J].Science, 2002, 298(5597): 1395-1401.
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  • 5Bassuny WM, Ihara K. A functional polymorphism in the promoter/enhancer region of the FOXP3/Scurfin gene associated with type 1 diabetes[J]. Immunogenetics, 2003, 55(3): 149-156.
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  • 7Bach JF. Regulatory T cells under scrutiny[J]. Nature Rev Immunol, 2003, 3(3): 189-198.
  • 8Bennett CL, Brunkow ME,Ramsdell F, et al. A rare polyadenylation signal mutation of the FOXP3 gene (AAUAAA→AAUGAA)leads to the IPEX syndrome [J]. Immunogenetics, 2001, 53(6):435-439.
  • 9Owen CJ, Jemmings CE, Imrie H, et al. Mutational analysis of the Foxp3 gene and evidence for genetic heterogeneity in the immunodysregulation, polyendocrinopathy, enteropathy syndrome[J].J Clin Endocrinol Metab, 2003, 88(12): 6034-6039.
  • 10Wildin RS, Smyk-Pearson S, Filipovich AH. Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome[J]. J Med Genet. 2002, 39(8): 537-545.

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医学综述
2008年 第11期

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