某农村地区高血压家族聚集性和遗传度的研究

Study on familial aggregation and heritability of hypertension in Korean population of rural area

目的探讨高血压家族聚集性及遗传度。方法采用遗传流行病学方法,对718名(286名先证者和432名对照)家系进行了家族聚集性、遗传方式及遗传度分析。结果先证者一级亲属高血压患病率为2.68%,与对照组的1.87%相比差异有显著性;2项分布显示,高血压家族中实际发病数超过其2项分布的理论概率范围,即高血压分布呈明显家族聚集现象;高血压的遗传度为14.31%(男5.04%,女22.44%)。结论遗传因素在韩国人高血压的发病中起一定的作用,但环境因素的作用可能比遗传因素更为重要。

[Objective] To investigate family aggregation and heritability of hypertension. [Methods] The family aggregation and hereditability of hypertension were evaluated by using a genetic epidemiologic study. The study was conducted in 718 pedigrees （286 probands and 432 controls） in South Korea.[Results] The total prevalence rate of the first-degree relatives was significantly higher in probands （2.68%） than that in controls （1.87%）. According to the results of binominal distribution analysis, the number of incidences for hypertension among families with history of hypertension was over the range of theoretical probability, it also indicated a phenomenon of familial aggregation in the distribution of hypertension, heritability of hypertension was 14.31 %（male 5.04%, female 22.44%）. [Conclusion] Genetic factors possibly have effects on the occurrence of hypertension in Korean population, but the environmental factors could be more important than genetic factors.