兔急性弥漫性颅内高压模型中经颅多普勒的改变

Changes of transcranial doppler sonography in model of acute diffuse intracranial hypertension in rabbits

目的采用兔急性弥漫性颅高压模型,研究弥漫性颅内压增高过程中经颅多普勒的变化规律。方法A组(对照组)8只,枕大池穿刺后不注入林格氏液;B组(实验组)12只,枕大池穿刺后逐步持续注入林格氏液。TCD持续监测同样时间。结果随着ICP的升高,TCD与急性弥漫性ICP增高有密切线性关系;TCD的变化发生在生命体征改变之前,更早于Cushing反应之前;在濒死前期,TCD出现一"反跳"现象,提示预后极差。结论TCD频谱的变化能较早地反映ICP的变化及颅内高压的严重程度,同时ICP增高晚期出现的特征性"反跳"现象为临床判断病情变化,治疗效果预后等提供了一定线索。

[Objective] To study the changes of the TCD flow spectra in acute diffuse intracranial hypertension model of rabbits. [Methods] The experiments were performed on the twelve rabbits （Group B）, these animals were continuously infused Ringer′s solution via the cistern occipital while in control group （Group A） were not infused in. TCD in different time and different intracranial pressure was monitored constantly. [Results] There was a closely linear correlation between the changes of the TCD flow spectra and the acute diffuse raised intracranial pressure （ICP）. The changes of the TCD flow spectra happened before the changes of vital signs, much earlier than the Cushing′s reaction occurred. In the stage of before death,＂rebounding＂ phenomenon occurred. That illustrated poor prognosis. [Conclusions] The changes of the TCD spectra can reflect the changes of ICP and the severity of ICP. The special ＂rebounding＂ phenomenon occurred in later stage of intracranial hypertension. It is highly important for doctors to evaluate the patient′s condition, therapeutic effects and prognosis.