摘要
介于脑部毛细血管与脑组织之间的血脑屏障是一层难以通过的生理屏障,大部分有中枢性作用效能的药物因不能通过血脑屏障而在临床上的运用受到限制,因此近年来针对能够通过血脑屏障脑部靶向给药技术的研究逐渐成为热点。
The existence of blood-brain barrier (BBB) is an unfavorable factor in the treat-ment of central nervous system (CNS) diseases. The following advances were reviewed in this paper: preparation methods of drug-loaded nanoparticles and the mechanism of crossing blood-brain barrier of nanoparticles.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2008年第10期1394-1398,共5页
China Journal of Modern Medicine
关键词
血脑屏障
纳米技术
脑部靶向给药
blood-brain barirer
nantechnology
brain targeted drug delivery