小儿麻甘冲剂澄清工艺的研究

Study on Clarification Process for Xiaoermagan Granules (Herba Ephedrae,etc. )

用乙醇、壳聚精、101果汁澄清剂、ZTC天然澄清剂处理小儿麻甘冲剂处方的水提液，应用高效液相色谱法测定其麻黄碱、伪麻黄碱含量．实验结果表明：壳聚糖处理的样品中麻黄碱、伪麻黄碱含量较未经任何澄清处理的样品含量为低、略低于醇沉法，101果汁澄清剂、ZTC天然澄清剂处理后样品含量低于壳聚糖处理的样品．正交试验方差分析表明，壳聚糖加入量、药液浓度、pH值在所选择的3个水平中对样品含量的影响无显著性差异．

The extracted liquid of Xiaoermagan Granules with water was managed with EtOH,chitosan, 101 juice clarifying agent and ITC natural clarifying agent,respectively. And ephdrine and d-Pseudo-ephedrine contents in them after management were determined by HPLC. As a result,the two components in sample managed with chitosan are lower than that in unmanaged samples,little lower than that of managed sample with EtOH,and higher than that of managed samples with 101 juice clarifying agent and ITC natural clarifying agent. The orthogonal test-variance analysis indicated that there was no significant difference observed in effects of adding amount of chitosan,liquid concentration, PH value on the two component contents in samples on 3 selected levels.