女性甲状腺功能亢进症患者的骨密度变化

Change in bone mineral density in female patients with hyperthyroidism

目的:观察女性甲状腺功能亢进症(甲亢)患者病程及绝经与否对骨密度的影响。方法:采用双能X线骨密度仪测定192例女性甲亢患者腰椎和髋部骨密度,分为绝经前和绝经后两组,按病程长短又分为短程和长程两亚组,并对两组测量结果进行分析。结果:绝经前甲亢病程长者L2及腰椎总体骨密度明显低于病程短者(P<0.05)。绝经后甲亢长程组腰椎及髋部各个测量部位的骨密度较短程者显著降低(P<0.05),在L2及髋部其差别尤其显著(P<0.01)。结论:病程及绝经与否影响着女性甲亢患者的骨密度。

Objective To investigate the effect of the course and menopause on the change of bone mineral density （BMD） in female patients with hyperthyroidism. Methods BMDs of hip and lumbar vertebrae were measured by dual-energy X-rays absorptiometry （DEXA） in the female patients （ n = 19 2, aged 14 - 7 2 ）. Patients were divided into 2 groups （ premenopausal and postmenopausal ） and 2 subgroups（ short-course and long-course）. The BMDs were compared between those of agematched, weight-matched, height-matched and body mass index matched control subgroups. Results In the premenopausal hyperthyroidic patients, only the BMDs of the second and total lumbar vertebrae with longcourse were significantly lower than those of shortcourse group （ P 〈 0. 05 ）. In the postmenopausal group with the long-course, each BMD measured had a lower level compared with that with short-course, of which the hip and the second lumber vertebrae were evident （ P 〈 0. 01 ）. Conclusion The course and menopause have an effect on the BMDs in female patients with hyperthyroidism.