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细胞色素氧化酶CYP1A2的研究进展 被引量：36

Advance in cytochrome P450 1A2
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摘要 CYP1A2是一种重要的细胞色素P450酶,可代谢多种临床常用药物,并参与活化许多前毒物和前致癌物。CYP1A2酶活性可受到基因多态性、药物、饮食等因素的影响,其中基因多态性是导致CYP1A2活性及可诱导性产生个体差异的基础,对CYP1A2基因多态性的鉴定分型在个体化用药中具有重要的指导意义。 CYP1 A2 is an important cytochrome P450 enzymes, which is involved in metabolism of many clinical drugs and activation of some precarcinogens. CYP1 A2 activity can be influenced by various factors including genetic polymorphism, drugs, food and so on, in which the CYP1 A2 genetic polymorphism is the basis of difference on the activity and induction of CYP1A2. Therefore, the genotyping of CYP1 A2 plays an important part in individualization of therapy.
作者 肖鹏 周宏灏
机构地区 中南大学临床药理研究所
出处 《中南大学学报（医学版）》 CAS CSCD 北大核心 2008年第5期456-460,共5页 Journal of Central South University ：Medical Science
关键词 CYP1A2 药物代谢 遗传多态性 CYP1 A2 drug metabolism genetic polymorphism
分类号 Q55 [生物学—生物化学]
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参考文献24

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中南大学学报（医学版）
2008年 第5期

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