放射性核素治疗癌转移性骨痛

Radionuc｜ide therapy of patients with metastastic bone pain

癌性骨转移原发病灶常见于前列腺癌、乳腺癌、肺癌等，转移发生的病理生理机制、疼痛机制目前不十分明确。止痛治疗尤其是对广泛骨转移性疼痛的治疗是临床医师面对的主要挑战，放射性核素及其标记药物治疗是一种有效、价廉、不良反应较小的治疗方法，对广泛转移的止痛治疗及微转移患者的治疗独具优势，目前有待充分利用。

Bone metastases are often the first sign of distant spread in breast, prostate, and lung cancers. The pathophysiology of bone metastasis is poorly understood and related complications is complex. Bone pain consequent to metastatic cancer continues to be a major therapeutic challenge for clinicians and its alleviation is crucial to improving the patient＇s quality of life. Targeted radionuclide therapy is an effective and cost efficient treatment for multi-site metastatic bone pain, its advantages may also include therapy for subclinical micro-or oligometastatic disease before clinical manifestation. But radionuclides remain underutilized in such treatments.