聚腺苷二磷酸核糖聚合酶抑制剂的作用机制和应用前景

The mechanism of action of poly （ADP-ribose） polymerases inhibitors and its application perspective

聚腺苷二磷酸核糖聚合酶家族由众多调控细胞进程的酶组成，其参与人体内多种生理及病理生理过程。近些年，人们对此酶及其抑制剂进行了广泛的研究，其中侧重于聚腺苷二磷酸核糖聚合酶抑制剂在辐射增敏、化学药物增敏、神经保护等方面所发挥的作用。现已有聚腺苷二磷酸核糖聚合酶抑制剂进入临床药物试验，预示其具有良好的应用前景。

[Abstract] Poly （ADP-ribose） polymerases （PARP） constitute a family of enzymes involved in the regulation of many cellular processes. It plays a vital role in many physical and physiopathological processes. In the past ten years scientists have conducted extensive research on PARP and its inhibitors, among which the role of PARP inhibitors in radiosensitization, chemopotentiation and neuroprotection have been placed close attention. There have been several PARP inhibitors entering the clinical trials, which predicts its sound application perspectives.