全中枢系统合并局部加量照射治疗颅内生殖细胞瘤

The prognostics analysis of whole nervous system irradiation combined local dose accumulating for patients with intracranial germinoma

目的回顾分析46例生殖细胞瘤患者行全中枢系统合并局部照射治疗的效果。方法对1995年至2006年我科治疗的诊断明确的生殖细胞瘤患者，放疔后长期随访，分析预后。结果46例生殖细胞瘤患者放疔后，5年、10年生存率分别为93．8％、82．6％，未发现有意义的预后因素。结论全中枢系统照射治疗应为颅内生殖细胞瘤必要的治疗方法。治疗结果满意，远期放射损伤很少。

Objective To analyze the result of whole nervous system and local site irradiation for 46 patients with intracranial germinoma. Methods Long term follow-up is exerted for these patients beween Octomber, 1995 and Octomber, 2006. The results is analysed. Results 5-year and 10-year survival rate is 93.8% and 82.6% respectively. No prognostic factors are effective statistically. Conclusion Whole central nervous irradiation for treatment of intracranial germinoma is essential. The results of the patients are satisfactory. Long-term radition brain injury is rare.