阿奇霉素对老年慢性阻塞性肺病患者茶碱药动学的影响

Effect of azithromycin on pharmacokinetics of theopltylline in patients with chronic obstructive pulmonary diseases

采用高效液相色谱法测定9名慢性阻塞性肺病患者口服茶碱缓释片3d后及加服阿奇霉素3d后茶碱血药浓度，拟合药动学参数；结果显示：患者合用阿奇霉素3d后，茶碱平均稳态血药浓度升高1．44±0．25mg·L-1，Cmax较用阿奇霉素前高，分别为10．5±2．1mg·L-1和12．5±2．1mg·L-1（P＜0．05）；其它药动学参数无明显改变（P＞0．05）。

Serum theophylline concentrations in 9 patients with chronic obstructive pulmonary diseases, after administration of theophylline sustained release tablets 3 days and after administration of azithromycin 3 days were detemined with high pressure liquid chromatography. Calculate pharmacokinetic parameters; After administration of azithromycin for 3 days, the mean serum theophylline concentration at steady-state was increased by 1. 44±0. 25mg. L-1,Cmax was higher than those obtained before azithromycin. They were 10. 5± 2. lmg. L-1 and 12. 5±2. 1mg. L-1 (P＜0. 05). But there was no signifcant variation in modification of other pharmacokinetic parameters (P ＞0. 05).