肺癌间质血管密度及临床意义

Relationship between microvessel density in lung cancer and clinical pathological features

[目的]评价肺癌间质血管密度对判定肺癌恶性程度的临床价值。[方法]采用免疫组化方法,对119例肺癌间质血管密度进行检测,并分析其与肺癌病理组织类型、临床分期、淋巴结转移程度的关系。[结果]肺癌间质血管密度在各组织类型肺癌差异有统计学意义(P<0.01),未分化癌具有较强的血管生成能力;I期肺癌中血管密度明显低于Ⅱ期和Ⅲ期肺癌(P<0.01),发生淋巴结转移组血管密度高于无淋巴结转移组(P<0.01)。[结论]肺癌间质血管密度可作为评价肺癌恶性程度的指标,肺癌间质血管密度高可能促进淋巴结转移发生和肺癌的发展。

[ objective] To measure the tumor angiogenesis in primary lung cancer and study the relationship between it and lymph node metastasis. [ Methods] Intratumor microvessel density was detected by using ABC immunohistochemistry. [ Results] Tumor microvessel density has relationship among all types of lung cancer （P 〈 0.01 ）, Microvessel density in stage Ⅰ is significantly lower than those in stage Ⅱ and Ⅲ （P 〈 0.01 ）. Microvessel density is higher in the tumors with lymph node metastasis than not （ P 〈 0.01 ）. [ Conclusion] Tunor angiogenesis play an important role in the growth and metastasis of lung cancer