巴曲酶对海马脑片缺氧损伤的保护作用

Protective effects of batroxobin on hypoxiainduced neuronal injury in hippocampal slices

本实验采用离体大鼠海马脑片缺氧模型，观察巴曲酶对缺氧后海马脑片ＣＡ１区诱发突触电位的影响。结果可见：用三种浓度巴曲酶孵育的海马脑片缺氧后ＰＶ消失时间均明显延迟，但对ＰＳ的消失时间无明显影响。提示：巴曲酶对海马神经元缺氧损伤具有一定保护作用。

With the hypoxic model of rat hippocampal slices,the effects of Batroxobin on evoked synaptic potentials in hippocampal CA1 region during hypoxia were investigated.The results showed that the disappearance time of PV induced by hypoxia was significantly prolonged by Batroxobin,while the PS was not affected.It suggested that Batroxobin could protect the neuron against hypoxic injury.