透明质酸在脑出血和腔隙性脑梗塞中病理作用的探讨

A pathological approach of hyaluronic acid in hemorrhage and lacunar infarction

本文对５７例急性脑出血和脑腔梗患者及３５例对照组血清透明质酸（ＨＡ）含量进行了测定，并与相应的临床指标（病程、血压及神经功能缺损评分等）、血液生化指标（血糖、血脂、纤维蛋白原及血液流变学等）和影像学指标进行了相关分析。结果表明：脑出血和脑腔梗组的ＨＡ含量明显高于对照组，腔梗组明显高于出血组（Ｐ＜０．０１）。脑出血组ＨＡ含量与纤维蛋白原含量呈明显负相关，与其它指标无相关性。而脑腔梗组ＨＡ含量与纤维蛋白原及其它指标均无相关性。

In this article,hyaluronic acid (HA) in serum of patients with cerebral hemorrhage and lacunar infarction were measured,corresponding clinical and blood biochemical parameters were also measured.Results showed:(1)HA in serum both hemorrhage and lacunar infarction group were significantly higher than normal group.Besides,HA in serum were significantly higher in lacunar infarction group than these in cerebral hemorrhage group.(2)No relationship was found between HA and their corresponding clinical and biochemical parameters in both tested groups.(3)There existed significant negative correlation between HA and fibrinogen in hemorrhage group.While,no correlation between HA and fibrinogen was found in lacunar infarction group.The level of fibrinogen in hemorrhage group was obviously higher than those in lacunar infarction group.