中国淡水鱼油的研究 Ⅲ淡水鱼油对高脂血症疗效的临床观察

FRESH WATER FISH OIL OF CHINA Ⅲ. THE THERAPEUTIC EFFICACY OF FRESH WATER FISH OIL PREPARATION ON HYPERLIPIDEMIC PATIENTS

高脂血症的患者血中EPA和DHA含量,EPA/AA和DHA/EPA值均低于健康对照组。以淡水鱼油乳化剂对44例高血脂症病人作小剂量的n-3不饱和脂肪酸的补充(EPA+DHA约1.59g/d),3～4w后,患者血浆中EPA和DHA分别增加了242%(P<0.01)和1018％(P<0.01),EPA/AA和DHA/EPA值亦显著提高;血浆TC、TG、LDL及Lp(a)分别降低19.6％(P<0.01)、23.9%(P<0.01)、24.2％(P<0.01)和22.3%(P<0.05),apoA,升高为10.1％(P<0.05)。观察结果提示,淡水鱼油有利于高脂血症和冠心病的防治。

The contents of EPA and DMA,the value of EPA/AA and DHA/EPA in blood of patients with hyperlipidemia were lower than in healthy people. In 44 patients with hyper-lipidemia.at 3-4 weeks treatment of freshwater fish oil emulsion (EPA+DHA 1. 59g/d),it led to increase in EPA(242%,P<0. 01)DHA(1018% ,P<0. 01) ,EPA/AA ,DHA/EPA and apoA,(10.1%,P<0. 05),and decrease in plasma TC(-19. 6%,P<0. 01),TG(-23. 9%,P <0. 01).LDL ( - 24. 2%,P<0. 01) and Lp(a) (- 22. 3%,P<0. 05). These data suggest that fresh waterfish oil is beneficial to prevention and treatment of coronary heart disease.