淋球菌对环丙氟哌酸的药物敏感度测定

Antibiotic susceptibility of Neisseria gonorrhoeae to ciprofiloxacin

为了解我国淋球菌对氟喹诺酮类药物的敏感性。以琼脂稀释法测定了１９９４年７月～１９９６年７月由４个城市分离的５３５株淋球菌对环丙氟哌酸的敏感性。环丙氟哌酸最小抑菌浓度的范围为０．００２～＞２ｍｇ／Ｌ。７３株（１３．６４％）对环丙氟哌酸耐药，４９株（９．１６％）对环丙氟哌酸敏感，４１３株（７７．１９％）为低敏。４个城市对氟喹诺酮耐药的淋球菌的比率介于７．４６％～２５．５５％。耐药菌株比率呈上升趋势。表明淋球菌对氟喹诺酮药物的耐药菌株已在我国出现。实验室应能识别这些耐药菌株。

To investigate the antibiotic susceptibility of Neisseria gonorrhoeae isolates to fluoroquinolone in China, 535 strains of Neisseria gonorrhoeae isolated in four cities from July 1994 to July 1996 were tested for susceptibility to ciprofloxacin by agar plate dilution method. The range of the minimum inhibitory concentrations(MICs) was between 0.002 and >2mg/L. A total of 73(13.64%) strains were found to be ciprofloxacin resistant. 49(9.16%) strains were susceptible to ciprofloxacin. 413(77.19%) strains were less sensitive. The percentage of fluoroquinoloneresistant Neisseria gonorrhoeae in four cities ranged from 7.46% to 25.55%. A trend towards increased resistance to ciprofloxacin was observed during the period. This study showed that strains resistant to fluoroquinolone group of antibiotics in Neisseria gonorrhoeae has been emerged in our country. It would be appropriate for clinical laboratories to test for these resistant strains and monitor their spread.