米非司酮用于足月妊娠引产时脐动脉血流的测定

Determination of Fetal Umbilical Artery Flow Velocity during Induction of Term Labor by Mifepristone

目的：评价米非司酮用于足月妊娠引产时对胎盘血液供应的影响。方法：将９７例妊娠３８～４２周具有引产指征的孕妇随机分为两组：治疗组（４９例）给予口服米非司酮，每次５０ｍｇ１２小时１次连续２天后，阴道置米索前列醇２５μｇ，１２小时１次；对照组（４８例）予静脉推注蒂洛安２００ｍｇ，每日１次连续３天后，静脉点滴催产素引产。两组孕妇均在用药前及用药后３６～４８小时行脐动脉血流速度测定，以收缩期血流速度峰值（Ｓ）与舒张末期血流速度峰值（Ｄ）的比值（Ｓ／Ｄ）为测定参数，观察用药前及用药后３６～４８小时的脐血流Ｓ／Ｄ值的改变。结果：两组用药前及用药后３６～４８小时的脐血流Ｓ／Ｄ值比较，差异无显著性（Ｐ＞０．０５）。结论：米非司酮５０ｍｇ１２小时１次连续２天口服用于足月妊娠引产不仅效果良好，且对胎盘血流动力学无显著影响。

Objective: To evaluate the effects of mifepristone for induction of term labor on blood supply of placenta. Methods: 97 pregnant women (38～42 gestational weeks) were recruited, and randomly allocated into 2 groups, group 1 (n=49) mifepristone was given orally 50mg q12h for 2 days followed by misoprostol intravaginally (25μg q12h); group 2 (n=48), Sodium prasterone sulfate intravenous injection of 200 mg qd for 3 days followed by oxytocin intravenous infusion. Fetal umbilical artery flow velocity was determined before and 36～48 hours after treatment to observe the variation of S/D value in both groups. Results: There were no significant variations of S/D value in both groups (P>0.05) .Conclusions: Mifipristone for induction of term labor (50mg q12h for 2days) is effective, and has no significant influence on the blood supply of placenta.