人轮状病毒感染母婴传播的临床研究

Human Rotavirus Infection in Perinatal Transmission

目的：了解人轮状病毒（ＨＲＶ）母婴感染的状况及对新生儿的影响。方法：应用反向－聚合酶链反应（ＲＴ－ＰＣＲ）方法对２５０例孕产妇宫颈分泌物、粪便及新生儿出生后３天内粪便进行轮状病毒检测。结果：孕产妇人轮状病毒肠道感染率及宫颈感染率分别为２６．０％及８．８％，新生儿出生３天内ＨＲＶ感染率分别为４．４％、１５．６％和２２．０％。ＨＲＶ感染的孕产妇所生新生儿感染率５２．３１％。结论：ＨＲＶ感染的孕产妇是新生儿感染的重要感染源，产道感染及院内感染是新生儿ＨＲＶ感染的重要传播途径。

Objective: To investigate the perinatal infection of human rotavirus (HRV) in pregnant women and the effect on their neonates. Methods: HRV was examined by RTPCR in cervical secretion and feces of 250 pregnant women and fecal samples of their neonates on the third postpartum day. Results: In pregnant women the HRV prevalence was 26.0% in feces and 8.8% in cervical secration, respectively. The infection rate of the 250 neonates in the first three days after birth was 4.4%、15.6% and 22.0%, respectively. The HRV infection rate in neonates of infected mothers was 52.31%. Conclusion: The infected mothers may be an important source for HRV infection of neonates. HRV transmitted via the labor tract and intrahospital transmission were the main sources for the neonatal infection.