国产厄贝沙坦对老年原发性高血压的疗效及对肾功能保护作用的研究

The effects of domestic irbesartan on blood pressure and renal function in the aged with primary hypertension

目的 评价国产厄贝沙坦对老年原发性高血压的疗效及对肾功能的保护作用。方法42例确诊为原发性高血压的老年患者，服用国产厄贝沙坦150mg，每日1次，每1～2周随访1次，若服药后降压效果不理想，可加大至300mg／d，治疗8周，监测治疗前后24h动态血压水平及肾功能指标。结果 国产厄贝沙坦治疗后，患者24h平均收缩压和舒张压、日间及夜间收缩压和舒张压均有明显下降（P〈0．05或〈0．01）；血及尿β2-微球蛋白明显减少[（5．9±3．3）μg/L比（2．6±2．6）μg/L，（811．2±97．2）mmol／L比（457．6±69．8）mmol／L]。结论 国产厄贝沙坦不仅对老年原发性高血压患者有良好的平稳降压效果，而且对其肾功能亦有良好的保护作用。

Objective To evaluate the effects of domestic irbesartan on blood pressure and renal function in the aged with primary hypertension. Methods Renal function, plasma and urine β2 microglobulin was measured and blood pressure was investigated by 24-hour ambulatory blood monitoring in 42 aged with primary hypertension who received domestic irbesartan （ 150 mg/d, followed up every 1-2 weeks. If the effect was not ideal, the dose could be added to 300 mg/d） in 8-week＇ s treatment. Results After the treatment, 24 hours mean systolic blood pressure, 24-hour mean diastolic blood pressure, mean day systolic blood pressure, mean day diastolic blood pressure, mean night systolic blood pressure, mean night diastolic blood pressure were significantly reduced. At the same time, domestic irbesartan induced a remarkable reduction of plasma and urine 13 2 microglobulin [ （5.9± 3.3 ） μg/L vs （ 2.6± 2.6） μg/L, （811.2 ± 97.2 ） mmol/L vs （457.6 ±69.8）mmol/L,respectively]. Conclusion The antihypertensive effects of domestic irbesartan can persist for 24-hour and can reduce urinary protein.