银杏叶注射液治疗椎-基底动脉供血不足的临床研究

Clinical study of Ginkgo Biloba Leaf Extract on treating vertebra arteriae basilaris blood-supply insufficiency

目的探讨银杏叶注射液治疗椎-基底动脉供血不足(VBI)的临床疗效。方法VBI患者102例,随机分为银杏叶注射液组(治疗组)和对照组。两组均口服尼莫地平片,治疗组加用银杏叶注射液,连用2个疗程(20d)后,评定疗效,并检测TCD和血液流变学各指标。结果治疗组58例中总有效例数为54例,总有效率93.1%;对照组44例中总有效例数为33例,总有效率75.0%,两组比较差异有统计学意义(P<0.05)。两组治疗后椎动脉(VA)、基底动脉(BA)、大脑后动脉(PCA)血流速度比较差异均有统计学意义(P<0.01),且两组治疗后血液流变学各指标在统计学上亦有显著性差异,表明银杏叶注射液具有显著改善脑血流的作用。结论银杏叶注射液是治疗椎-基底动脉供血不足的有效药物。

Objective To explore the clinical treatment effect of Ginkgo Biloba Leaf Extract on treating vertebra arteriae basilaris blood-supply insufficiency（VBI）. Methods 102 cases VBI patients were randomly individed into Ginkgo Biloba Leaf Extract group （ treatment group） and control group. Two groups patients were given Nimodipine Tablets,hte treatment group patients were added Ginkgo Biloba Leaf Extract injection. After continuous use two course of treatment （ 20 days） , clinical treatment effects were evaluated and transcranial Doppler（TCD） and hemorrheology was detected. Results Treatment group and control group, total effective rates were separately 93. 1% and 75.0% （ P 〈 0. 05 ） ; blood flow rates of arteria vertebralis （ VA ） and arteria basilaris（ BA ） and posterior cerebral artery（ PCA ） between 2 groups had very significant deviation（ P 〈 0.01 ） , all hemorrheology indexs between 2 groups statistically had differenece（ P 〈0. 05 or 〈0. 01 ）after treatment. Indicated Ginkgo Biloba Leaf Extract had a significant action on improving cerebral blood flow. Conclusion Ginkgo Biloba Leaf Extract was a active drug on treating vertebra arteriae basilaris blood-supply insufficiency （VBI）.