辅酶Q_(10)在体外循环下对酶学及心肌超微结构的影响

Effect of Coenzyme Q_10 on Enzymes and Myocardial Ultrastructure under Cardiopulmonary Bypass

将体外循环心脏瓣膜置换术患者２４例分为两组。对照组应用心肌冷停跳液灌注，试验组于冷停跳液中加入辅酶Ｑ１０（２ｍｇ／ｋｇ）。观察血浆ＭＤＡ，红细胞ＳＯＤ，血清ＣＰＫ与ＣＫ—ＭＢ，心肌超微结构，临床表现。结果：（１）试验组氧自由基产生减少，酶学有降低趋势，心肌超微结构损伤较轻。（２）再灌注心律失常、术后室性心律失常与低心排发生人数较少。结论：冷停跳液加入辅酶Ｑ１０灌注对体外循环下心肌缺血再灌注损伤有一定保护性作用，应用于临床是可行的。

Twenty-four patients with valve replacement were randomly divided into two groups during extracorporeal circulation.Only cold crystalloid cardioplegia fluid was used in the control group.In coenzyme Q_10 group,coenzyme Q10 (zmg/kg) was added in the cold cardioplegia fluid.Plasma MDA、RBC、SOD、serum CPK and CKMB、myocardial ultrastructure and clinical data were observed.The results were:1) In coenzyme Q10 group,prcduction of oxygen free radical was decreased much significantly,the enzymes had the tendency to decline and the myocardial ultrastructure was better preserved;2) The incidence of reperfusedinduced arrhythmias,postoperative arrhythmias or low output syndrome after operations was lowes Lower in the enzyme Q10 group.The data suggested that using infusion with cold cardioplegia fluid including coenyme Q10 there was certain protective effect on myocardial ischemia reperfusion injury during cardiopulmonary bypass and this method was feasible clinicaly.