HBV感染者血清中前-S1抗原与临床型别关系的研究

STUDY ON RELATIONSHIP OF PRE-S1 ANTIGEN IN SERA OF PATIENTS WITH HBV AND CLINICAL TYPES

[目的]了解HBV感染者血清中前-S1抗原的检出与临床型别的关系。[方法]采用ELISA法,对370名临床不同型别的HBV感染者进行HBV前-S1抗原和ALT检测。[结果]不同临床型别乙型肝炎患者和无症状HBV感染者中,均有前-S1抗原检测阳性者。各型乙型肝炎患者血清中前-S1抗原检出率明显高于无症状HBV感染携带者,差异有统计学意义(χ2=37.15、15.18、4.90,P﹤0.05)。不同临床型别乙型肝炎患者血清ALT也均明显高于无症状HBV感染携带者。[结论]无症状HBV感染携带者和不同型别乙型肝炎患者血清中前-S1抗原均有检出,但不同型别乙型肝炎患者血清中前-S1抗原检出明显高于无症状HBV感染携带者,差异有统计学意义(t=27.25、22.94、15.48,P﹤0.001)。前-S1S1抗原与HBV复制有关,必须重视对无症状HBV感染者中前-S1抗原的检测。ALT升高与前-S1抗原检出有明显相关性。

[Objective] To understand the relationship of pre-s1 antigen in sera of patients with HBV and clinical types. [Methods] ELISA was used to detect pre-s1 antigen in sera of 370 patients with HBV. [ReSults] Pre-s1 antigen was detected in all different clinical types patients with HBV and in patients who carried HBV and had no symptoms. The detection rate was significantly higher in different clinical types patients with HBV than in patients carried HBV （X^ = 37.15, 15.18, 4.90, P 〈 0.05 ）. ALT was also significantly higher in different clinical types patients with hepatitis B than in patients carried HBV and had no clinical symptoms. [Conclusions] Pre-s1 antigen is detected in all different clinical types patients with HBV and in patients who carry HBV and have no clinical symptoms. But positive rate of pre-s1 antigen is significantly higher in different clinical types patients with HBV than in patients carry HBV and have no clinical symptoms （t =27.25, 22.94, 15.48, P 〈 0.001 ）. Pre-s1 antigen is relevant to HBV copy. The increase of ALT is significantly relevant to detection of pre-s1 antigen.