妊娠高血压疾病患者胎盘组织中LIF的表达及意义

Expression and significance of LIF in placenta of patients with hypertensive disorder complicating pregnancy

目的了解妊娠高血压疾病患者胎盘组织中LIF的表达变化,探讨其在妊娠高血压疾病发病中的作用。方法采用免疫组化染色测定胎盘组织中LIF的表达,其中正常妊娠组30例,轻度子痫前期组18例,重度子痫前期组17例。结果LIF在正常妊娠及妊娠高血压疾病胎盘组织中均有表达,主要在滋养细胞胞浆中染色较明显。轻度子痫前期组及重度子痫前期组与正常妊娠组比较,胎盘组织中LIF的表达强度均明显减弱,差异有统计学意义(P<0.01);且随着病情加重其表达强度呈逐渐减弱趋势。结论LIF在胎盘组织中的表达下降,影响了滋养细胞浸润能力,可能在妊娠高血压疾病发病过程具有一定作用。

Objective To study the changes of the LIF expression in placenta of patients with hypertensive disorder complicating pregnancy（HDCP）, and to assess the effects of LIF on the pathogenesis of HDCP. Methods The expression of LIF cases in placenta of normal pregnancy group（30 cases） ,mild preeclampsia group（ 18 cases）and serious preeclampsia group （17 cases）was examed by immunhistochemical staining. Results LIF expression was found in placentas in all three groups pregnancy and hypertensive disorder complicating pregnancy, mainly located in the cytoplasm of trophoblast cells. The expression of LIF in preeclampsia groups was significantly decreased than those of normal pregnancy group （ P 〈 0.01 ）, and the expression of LIF decreased with the advance of the disease in preeclampsia groups. Conclusion The decreased expression of LIF in placentas of preeclampsia can affect the trophoblastic invasion, which might play an important role in the pathogenesis of HDCP.