2型糖尿病肥胖患者代谢紊乱特征及血清同型半胱氨酸水平的变化

The characteristics of metabolism disorder and the changes of serum homocysteine(tHcy) level in patients with obese type 2 diabetes mellitus

目的观察肥胖2型糖尿病患者的代谢特征及血清同型半胱氨酸(Hcy)的表达变化,为其综合治疗提供依据。方法比较肥胖和非肥胖2型糖尿病患者的血压、血脂、血尿酸、血糖、血胰岛素及血清Hcy水平的变化。结果肥胖组总胆固醇(TG)、低密度脂蛋白胆固醇(LDL-C)、舒张压(DBP)、尿酸(UA)、肿瘤坏死因子(TNF-α)和Hcy明显高于非肥胖组(P<0.05,0.01);高密度脂蛋白-胆固醇(HDL-C)、胰岛素酸性指数(ISI)明显低于非肥胖组;而血总胆固醇(TC)、收缩压(SBP)2组之间差异无统计学意义(P>0.05);高血压组Hcy明显高于正常血压组(P<0.05)。结论2型糖尿病肥胖患者胰岛素抵抗(IR)、高胰岛素血症、高血压、高Hcy及脂代谢紊乱等均较非肥胖者明显。

Objective To investigate the characteristics of metabohsm disorder and the changes of serum homocysteine（tHcy） level patients with in obese type 2 diabetes mellitus patients and provide basis for the comprehensive treatment. Methods Compare the levels of blood pressure, lipids, uric acid, glucose, insulin and the changes of tHcy between obese and nonobese type 2 diabetes melhtus patients. Results In the obese groups, the TG.LDL-C.DBP. UA. TNF-αand Hcy were significantly higher than those of the nonobese groups;the HDL-C.ISI were much lower than those of nonobese groups; TC, SBP had no significant difference in the two groups, tHcy was positively correlated with DBP. Conclousion The IR, hyperinsulinemia, hypertension, the disorder of lipid metabolism and tHcy level were more obvious in the obese groups compared with those of nonobese.