柔肝养阴活血法对急性心肌梗死后心功能影响

Clinical research on the effect of Rouganyangyinhuoxue capsule on cardiac function after acute myocardial infarction

目的探讨柔肝养阴活血法对急性心肌梗死(AMI)后心功能的影响。方法将82例AMI患者随机分为2组,对照组42例予单纯西医常规治疗;治疗组40例在西医常规治疗基础上予柔肝养阴活血胶囊,每次4粒,每日3次口服,连服6个月。应用心脏超声检查2组患者AMI后(14±2)d及1个疗程后左室舒张末径(LVEDd)、左室射血分数(LVEF)、二尖瓣舒张早期血流速度峰值(E)、二尖瓣舒张晚期血流速度峰值(A),并计算E/A。结果2组AMI后(14±2)d LVEDd、LVEF及E/A比较差异无统计学意义(P>0.05);但1个疗程后2组LVEDd、LVEF及E/A比较差异均有统计学意义(P<0.01)。结论柔肝养阴活血法可明显改善AMI后心功能。

Objective To investigate the clinical therapeutic effect of Rouganyangyinhuoxue capsule on the dysfunction of heart after the AMI. Methods 82 patients with AMI were divided randomly into 2 groups, with 42 in control group and 40 in treatment group. The control group was treated by routine west medicine only, while the treatment group, on the basis of control group, was treated by Rouganyangyinhuoxue capsule, 4 pills each time, 4 times a day, per os. Both groups have the same treatment course of 6 months. By cardiac ultrasonic contrast, both groups were examined before discharge and 6 months after the discharge the LVEDd, LVEF, the peak value of tachogram at prediastole （E）, the peak value of tachogram at diastasis period （A） and calculated the value of E/A. Results There was no significant difference between LVEDd, LVEF and E/A in two groups after AMI （14 ± 2） days （ P 〉 0.05）. There was significant difference between LVEDd, LVEF and E/A 6 months after the discharge （ P 〈 0.01）. Conclusion There is a significant therapeutic effect of Rouganyangyinhuoxue capsule on the dysfimction of heart after the AMI.