摘要
苯乙酮与甲胺盐酸盐、多聚甲醛进行M ann ich反应生成3-甲胺基-1-苯基丙酮盐酸盐(1);1在甲醇中用硼氢化钾还原制备3-甲胺基-1-苯基丙醇(2);2经醚化、成盐合成了抗抑郁药———盐酸氟西汀(4),总收率41%。4的结构经1H NMR和MS表征。
Fluoxetine hydrochloride（4） in overall yield of 41.0% was synthesized by a four-step reaction in which acetophenone reacted with methylamine hydrochloride and paraformaldehyde to obtain 3-methylaminopropiophenone hydrochloride （1）; then 1 was reduced by potassium borohydride i,n methanol to prepare 3-methylamino-1-phenylpropanol（2） ; finally, 2 reacted with 4-chlorobenzo-trif- luoride and formed salt. The structrue of 4 was characterized by ^1H NMR and MS.
出处
《合成化学》
CAS
CSCD
2008年第3期354-355,361,共3页
Chinese Journal of Synthetic Chemistry
基金
国家自然科学基金资助项目(20576094)
