5-羟基-5-甲基-3,4-二苯基异唑的合成

Synthesis of 5-Hydroxy-5-methyl-3,4-diphenylisoxazole

以苯乙氰和苯甲酸甲酯为起始原料,经Claisen缩合、羟胺化、环合制得伐地考昔的关键中间体——5-羟基-5-甲基-3,4-二苯基异唑,总产率54.68%。其结构经1HNMR,IR和MS确证。

A key intermediate of valdecoxib, 5-hydroxy-5-methyl-3,4-diphenylisoxazoline in total yield of 54.68% was prepared by Claisen condensation, hydroxylamine and cyclozation from phenyla- cetonitrile and benzoic acid methyl ester. The structrue was confirmed by ^1H NMR, IR and MS.