不同铁营养强化剂对贫血学生体内铁储量的影响

Influence of Iron Fortificants on Body Iron Store of Anemia Students

目的观察NaFeEDTA、FeSO4及电解质铁对贫血学生血红蛋白和体内铁储量的影响。方法将418名11～18岁贫血学生分为4组:对照组、NaFeEDTA组、FeSO4组和电解质铁组。通过强化面粉进行6个月铁补充,每公斤面粉铁强化量分别NaFeEDTA20mg、FeSO430mg、电解质铁60mg,对照组为同等级普通面粉。在0、2、4和6个月时,分别取血测定全血血红蛋白和血清铁蛋白、运铁蛋白受体,并通过铁蛋白和运铁蛋白受体计算体内铁储量。结果各观察组通过强化面粉平均每日铁摄入量:NaFeEDTA组6.6mg、FeSO4组11mg、电解质铁组22mg。NaFeEDTA组、FeSO4组和电解质铁组在干预6个月后血红蛋白升高17.5、9.3和3.9g/L;铁蛋白水平上升14.0、5.0、1.9ng/ml。转运蛋白受体降低12.9、8.8和2.9nmol/L。NaFeEDTA和FeSO4组铁储量与血红蛋白水平呈正相关。而对照组各项检验指标干预前后差异无统计学意义。结论NaFeEDTA强化面粉升高血红蛋白和增加人体铁储量的作用优于FeSO4强化面粉,FeSO4强化面粉优于电解质铁强化面粉。

Objective To observe the different effects of electrolytic iron, FeSO4 and NaFeEDTA on body iron store of anemic school students. Method 418 anemic students, aged 11 to 18 years old, were divided into four groups and each group was supplied with an iron fortificant through wheat flour as food vehicle in six months. The fortification level of electrolytic iron, FeSO4and NaFeEDTA were 60 mg Fe/kg, 30 mg Fe/kg and 20 mg Fe/kg respectively. The control group was supplied with none fortified flour. Blood samples were collected at 0, 2, g and 6 months and Hb, SF and TfR were measured and body iron store were calculated with SF and TfR. Results In three tested groups of NaFeEDTA, FeSO4, and electrolytic iron, the daily iron intake were 6.6 mg, 11 mg and 22 mg, Hb levels increased by 17.5, 9.3 and 3.9 g/L, increments of SF levels lg.0, 5, 1.9 ng/ml, TfR levels decreased by 12.9, 8.8 and 2.9 nmol/L respectively. NaFeEDTA and FeSO4 had positive effects on body iron in anemic students. Those parameters did not showe significant change in control group. Conclusion NaFeEDTA was better than that of FeSO4 while electrolytic iron showed less effect on body iron store on anemic students.