他莫西芬治疗乳腺增生的临床研究

Clinical Study on Treatment of Breast Hyperplasia by Tamoxifen

目的探讨他莫西芬(TAM)治疗乳腺增生症的临床效果。方法门诊随机选择1 820例明确诊断为乳腺增生患者有明显疼痛症状并伴有腺体组织增厚者采用他莫西芬治疗;同样症状者应用乳癖消治疗乳腺增生症900例;观察两组用药前后黄体期血清雌二醇(E2)和孕酮(P)含量,比较两组临床效果和不良反应发生率。结果黄体期血清E2和P的恢复,他莫西芬组明显优于乳癖消组(P<0.01)。结论他莫西芬能降低血清E2含量,消除疼痛及肿块,疗效好不良反应少。是目前较为理想的治疗乳腺增生症的药物。

Objective To explore the clinical effect of tamoxifen for breast hyperplasia. Methods Levels of serum estradio （E2 ） and progesterone （P） during corpus lutein phase were tested. Including tamoxifen group （TG） in 1 820 cases and Rupixiao group （RG）in 900 cases. Additionaly, comparison of the clinical effect and side effect of the drugs between the 2 groups was also studied. Results （1）TG was better than RG in the recovery of serum E2 and P（ P 〈 0. 001 ） ; （2）TG was superior to RG in clinical effects;（3）Rupixiao had no side effect while tamoxifen had a low incidence of slight side effect,but it could disappear after discontinue the drug;（4）the rate of relapse was higher in RG than that in TG during the follow - up period （ P 〈 0.01 ）. Conclusion Tamoxifen can reduce serum E2 content, eliminate the patitent＇ s pain and the lumps, tamoxifen can get an obvious effect. Without side effect. Tamoxifen is a satisfactory drug for breast hyperplasia at present.