结节性甲状腺肿血清胰岛素样生长因子-1水平与摄^131 Ⅰ率相关性研究

Study on the correlation of serum insulin-like growth factor-1 and radioactive iodine uptake rate in patients with nodular goiter

目的 研究结节性甲状腺肿患者血清胰岛素样生长因子-1（IGF-1）水平与甲状腺摄日Ⅰ率的相关性，为临床鉴别甲状腺结节的性质寻找更简捷、安全的方法。方法60例甲状腺结节患者分为热结节组（30例）和冷结节组（30例），以常规体检的健康人员30例作为对照组。采用放射免疫分析法检测血清IGF-1、游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）、TSH的含量，常规放射性核素扫描技术检测甲状腺摄^131 Ⅰ率。结果 与对照组比较，热结节组患者血清IGF-1[（315．86±22．74）μg/L]、FT3[（15．32±8．65）μmol／L FT4[（86．82±35．22）pmol／L]水平明显增高，摄^131 Ⅰ率（0．64±0．17）明显增高，血清TSH[（0．284-0．31）mU/L]水平明显降低，P〈0．01。热结节组IGF-1水平与摄^131Ⅰ率呈正相关（r=0．835），与TSH水平呈轻度负相关（r=-0．326）。而冷结节组患者血清IGF-1、FT3、FT4、TSH水平与对照组比较差异无统计学意义（P〉0．05）。结论 血清IGF-1水平与甲状腺摄^131 Ⅰ率有一定的相关．陛。

Objective To study the correlation of the serum insulin-like growth factor- 1 （IGF-1） level and the radioactive iodine uptake rate in patients with nodular goiter, to explore a simple and safty methods of identifying different kinds of thyroid nodule. Methods Sixty diagnosed cases was selected into hot nodule group（ 30 cases ） and cool nodule group（ 30 cases ）, and 30 healthy people were selected into the healthy control group. Measured the IGF-1, FT3, FT4, TSH level of each group by radioimmunoassay, and measured the radioactive iodine uptake rate by radionuclear technique. Results To compare with healthy control group, the levels of serum IGF-1, FT3, FT4 and the radioactive iodine uptake rate of hot nodule group were increased obviously , but the serum TSH was decreased significantly, and the level of IGF-1 had positive correlation with the radioactive iodine uptake rate （ r = 0.835） in the same group. Meanwhile, the 1 evel of IGF-1 had negative correlation with the level of TSH （r = -0.326）. In cool nodule group, the levels of serum IGF-1,FT3,FT4, TSH had no significant difference compared with healthy control group （P 〉 0.05 ）. Conclusion The level of IGF-1 and radioactive iodine uptake rate in patients with nodular goiter has certain correlation.