期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

肥胖症患者脂肪组织中组织蛋白酶K的表达及其功能初探 被引量：2

Investigation of the expression and the function of cathepsin K (CTSK) gene in obesity subjects
下载PDF
导出
摘要 研究组织蛋白酶K(cathepsin K,CTSK)在肥胖症患者脂肪组织中的表达及其在脂肪细胞分化中所起的作用。采用半定量RT-PCR及Western-blot分析显示肥胖组脂肪组织CTSK水平显著高于对照组,其表达随脂肪细胞分化成熟而逐渐增加。脂肪组织CTSK水平是肥胖症和脂质生成的一个较为敏感的标志物。 Semi-quantitative RT-PCR and immunoblotting analyses were used to investigate the expression of CTSK and its role in 3T3-L1 cell differentiation. The expression of CTSK gene was remarkably higher in obese patients than in the control group, and was increased gradually during adipocyte differentiation. CTSK gene is possibly involved in the adipocyte differentiation and the onset of obesity.
作者 尹晓 陈述林 刘志芬 骆天红 李果 罗敏
机构地区 济南市中心医院内分泌科 烟台毓璜顶医院 上海市瑞金医院内分泌研究所
出处 《中国糖尿病杂志》 CAS CSCD 北大核心 2008年第5期265-266,共2页 Chinese Journal of Diabetes
关键词 组织蛋白酶K 肥胖症 脂肪组织 Cathepsin K Obesity Adipose tissue
分类号 R589.2 [医药卫生—内分泌] R977 [医药卫生—药品]
  • 相关文献

参考文献4

  • 1Nelson BA, Robinson KA, Buse MG. High glucose and glucosamine induce insulin resistance via different mechanisms in 3T3-L1 adipocytes. Diabetes, 2000, 49:981-991.
  • 2Chiellini C, Costa M, Novelli SE, et al. Identification of cathepsin K as a novel marker of adiposity in white adipose tissue. J Cell Physiol, 2003, 195:309-321.
  • 3Sasaki T, Gohring W, Man K. limited cleavage of extracellular matrix protein BM-40 by matrix metalloproteinases increases its affinity for collagens. J Biol Chem, 1997,272 : 9237-9243.
  • 4Bouloumie A, Sengenes C, Portolan G, et al. Adipocyte produces matrix metalloproteinases 2 and 9: involvement in adipose differentiation. Diabetes, 2001,50 : 2080-2086.

同被引文献35

  • 1麻宏伟,姜俊,吕峻峰,郭然,牛国辉.X-连锁迟发性脊椎骨骺发育不良SEDL基因剪接受体突变导致潜在剪接位点激活(英文)[J].中华医学遗传学杂志,2005,22(3):251-253. 被引量：6
  • 2Abrahamson M,Alvarez-Fernandez M,Nathanson CM. Cystatins[J].Biochem Soc Symup,2003.179-199.
  • 3Jedeszko G,Sloane BF. Cysteine cathepsins in human cancer[J].Biological Chemistry,2004,(11):1017-1027.doi:10.1515/BC.2004.132.
  • 4Gocheva V,Zeng W,Ke D. Distinct roles for cysteine cathepsin genes in multistage tumorigenesis[J].Genes and Development,2006.543-556.doi:10.1101/gad.1407406.
  • 5Szumilo J,Burdan F,Zinkiewicz K. Expression of syndecan-1 and cathepsins D and K in advanced esophageal squamous cell carcinoma[J].Folia Histochemica et Cytobiologica,2009.571-518.doi:10.2478/v10042-008-0012-8.
  • 6Kleer CG,Bloushtain-Qimron N,Chen YH. Epithelial and stromal cathepsin K and CXCL14 expression in breast tumor progression[J].Clinical Cancer Research,2008,(17):5357-5367.doi:10.1158/1078-0432.CCR-08-0732.
  • 7Yan X,Takahara M,Xie L. Cathepsin K expression:a useful marker for the differential diagnosis of dermatofibroma and dermatofibrnsarcoma protuberans[J].Histopathology,2010.486-488.doi:10.1111/j.1365-2559.2010.03628.x.
  • 8Bühling F,Waldburg N,Gerber A. Cathepsin K expression in human lung[J].Advances in Experimental Medicine and Biology,2000.281-286.
  • 9Brubaker KD,Vessella RL,True LD. Cathepsin K mRNA and protein expression in prostate cancer progression[J].Journal of Bone and Mineral Research,2003,(2):222-230.doi:10.1359/jbmr.2003.18.2.222.
  • 10Rapa I,Volante M,Cappia S. Cathepsin K is selectively expressed in the stroma of lung adenooarcinoma but not in bronchioloalveolar carcinoma.A useful marker of invasive growth[J].American Journal of Clinical Pathology,2006.847-854.doi:10.1309/Q96AYDAAJ3E1TNWT.

引证文献2

二级引证文献5

中国糖尿病杂志
2008年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部