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初诊2型糖尿病患者短期强化治疗的疗效 被引量：12

Therapeuic effects of short-term intensive anti-diabetic therapy in newly diagnosed type 2 diabetic patients
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摘要 使用甘精胰岛素联合二甲双胍或格列美脲联合二甲双胍进行3个月短期强化治疗,两组患者的FPG和HbA1c均获得良好控制,第一时相和第二时相胰岛素和C肽分泌量明显增加、胰岛素抵抗显著改善。 36 newly diagnosd type 2 diabetic patients were treated with insulin glargine plus metformin or glimepiride plus metformin for 3 months. Excellent control of FBG and HbA, c was achieved in both groups after 3 months’ intensive treatment. The β-cell hypofunction and insulin resistance were improved significantly in both groups.
作者 王茜 沈备 覃又文 刘超
机构地区 南京医科大学第一附属医院内分泌科
出处 《中国糖尿病杂志》 CAS CSCD 北大核心 2008年第5期297-298,共2页 Chinese Journal of Diabetes
关键词 糖尿病 2型 初诊 Β细胞功能 胰岛素抵抗 Diabetes mellitus, type 2, newly diagnosed β-cell function Insulin resistance Blood glucose
分类号 R587.1 [医药卫生—内分泌] R977.15 [医药卫生—药品]
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参考文献5

  • 1Li YB, Xu W, Liao ZH, et al. Induction of long-term glycemic control in newly diagnosed type 2 diabetic patients is associated with improvement of β-cell function. Diabetes care, 2004, 271 2597-2602.
  • 2Ryan EA, Imes S, Wallace C, Short-term intensive insulin therapy in newly diagnosed type 2 diabetes. Diabetes Care, 2004, 27: 1028-1032.
  • 3UK Prospective Diabetes Study Group, Intensive blood-glucose control with sulfonylurea or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet, 1998,352:837-853.
  • 4UK Prospective Diabetes Study Group, Effect of intensive bloodglucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet, 1998,352: 854-865.
  • 5McFarlane SI, Chaiken RL, Hirsch S, el al, Near-normoglycaemic remission in African-Americans with Type 2 diabetes mellitus is associated with recovery of beta cell ruction. Diabetes Med, 2001, 18:10-16.

同被引文献62

  • 1黄云鸿,蒋筠,吴艺捷,彭永德.格列吡嗪控释片联用甘精胰岛素的疗效及β细胞功能变化[J].中华内分泌代谢杂志,2006,22(4):321-322. 被引量：26
  • 2张波,安雅莉,巩秋红,帅英,卜石,陈燕燕,张金苹,杨文英,刘雪丽,李光伟.短期胰岛素强化治疗诱导2型糖尿病患者长期缓解的预测因素[J].中华内分泌代谢杂志,2007,23(2):134-138. 被引量：95
  • 3Taki H, Maki T, Iso T, et al. Postmarketing study of nateglinide in Japan: treatment of medication-native patients with type 2 diabetes. Adv Ther, 2005,22(6):621.
  • 4Yin J, Yang G, Cben Y. Rapid and efficient chiral separation of nateglinide and its L-enantiomer on monolithic molecularly imprinted polymers. J Chromatogr A, 2005,1090(1):68.
  • 5Gefieh J, Raskin P, Jean-Louis, et al. Preserve-beta: two-year efficacy and safety of initial combination therapy with nateglinide or glyburide plus mefformin. Diabetes Care, 2005,28(9):2093.
  • 6Campbell IW. Nateglinide-current and future role in the treatment of patients with type 2 diabetes mellitus. Int J Clin Fract, 2005,59(10):1218.
  • 7Diabetes Control and Complications Trial Research Group( DC- CP). The effect of intensive treatment of diabetes on the development and progression of long - time complications in insulin - dependent di- abetes mellitus. N Engl J Med 1993;329:977 -986.
  • 8UK Prospective Diabetes Study ( UKPDS ) Group. Lntensive blood glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes. Lancet 1998 ;352:837 - 853.
  • 9Ilkova H,Glaser B ,Tunckale A,et al. Induction of Long - term glycemic control in newly diagnosed type 2 diabetes patients by transi- ent intensive insulin treatment. Diabetes Care 1997 ;20:1353 - 1356.
  • 10Diabetes Control and Complications Trial Research Group(DCCP). The effect of intensive treatment of diabetes on the development and progression of long-time complications in insulin-dependent diabetes mellitus.N EngI J Med,1993,329:977-986.

引证文献12

二级引证文献109

中国糖尿病杂志
2008年 第5期

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